C-5 HYDROXYETHYL AND HYDROXYPROPYL ACYCLONUCLEOSIDES AS SUBSTRATES FOR THYMIDINE KINASE OF HERPES SIMPLEX VIRUS TYPE 1 (HSV-1 TK): SYNTHESES AND BIOLOGICAL EVALUATION

The efficient syntheses of 5-(2-hydroxyethyl)- and 5-(3-hydroxypropyl)-substituted pyrimidine derivatives bearing 2,3-dihydroxypropyl, acyclovir-, ganciclovir- and penciclovir-like side chains are reported.A synthetic approach that included toothbrush the alkylation of an N-anionic-5-substituted pyrimidine intermediate (method A) provided the targe

Abstract Aim To describe the clinical nurse specialist role and its outcomes and Vanadium challenges.Design Participatory Action Research conducted in Finland between the fall of 2017 and the end of 2018.Methods A core participatory action research team (n = 10) led the design, implementation and evaluation of the research.Multiple data collection

The disasters of encounter of extreme rainstorm and high tide level will aggravate the flood in Headband coastal cities.In order to explore the impact of the encounter of rainstorm and tide on flood control and drainage in coastal cities,based on the annual maximum 1 day rainfall and its corresponding tide level data of Chiwan Station in Shenzhen f

We present a severe case of progressive autoimmune toothbrush pneumonitis requiring surgical intervention in a patient with the monogenic syndrome, autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).APECED is caused by loss-of-function mutations in the autoimmune regulator (AIRE) gene, which lead to impaired central immune tole